As anyone who has been diagnosed with celiac disease (or anyone whose loved ones have been diagnosed) knows, the process from symptoms to diagnosis can be laborious. Once you find a doctor to connect the dots, though, you still need to get the right blood tests (and sometimes an endoscopy) to confirm that gluten is the culprit.
New research out of Europe indicates that the age of the patient plays a significant role in determining which tests to use: children under two years old, they found, require different tests than older children and adults.
The researchers, affiliated with a number of hospitals and universities in Germany, Belgium, Austria, and the Netherlands, examined 184 children of up to two years old. Of the 184, 42 had celiac disease but were not following a gluten-free diet, and 142 were a control group.
Blood samples were taken and testsed for a variety of antibodies: IgA- and IgG-anti0dGli, IgA- and IgG-anti-nGli, IgA- and IgG-anti-tTG, and IGA-EmA (Wondering what these are? Pop over to the Celiac Disease Foundation for a list of recommended blood tests for diagnosing celiac disease).
The researchers were looking at the results for a number of measures, which boil down, generally, to:
- sensitivity (essentially the percent of positives that were correct)
- specificity (essentially the percent of negatives that were correct)
Of the range of tests, only those for IgG-anti-dGli, IgA-anti-tTG, and IgA-EmA were sufficiently sensitive, specific, and precise.
What this boils down to is that parents or guardians who are bringing a very young child for blood tests may want to skip the anti-nGli tests altogether.
If you’ve been through the process of diagnosing an infant or young toddler with celiac disease, what steps did you have to take? What blood tests were run, and if you ran the anti-nGli test did the results seem out of sync with the others?