Update on Possible Future Gluten-Killing Drug

Whilst I’m not exactly holding my breath for a cure, news of possible future celiac disease treatments are always pretty exciting.

After positive results from a Phase 11a trial with an experimental drug called Alvine AVL003, a company called Abbvie have secured the rights to the treatment, paying Alvine $70 million in upfront costs. Alvine is getting ready for a Phase 11b trial which will involve 500 patients.

The way the drug works is similar to lactase pills, which many sufferers of lactose intolerance take. An enzyme breaks down a chemical that the body cannot deal with.

In the case of this gluten-killing drug, ALV003 contains two proteases, enzymes that chop up proteins specific to gluten, which have been effective and safe in Phases 1 and 11a clinical trials in comparison to placebo.

“A collaboration between Alvine and AbbVie combines our respective strengths and expertise in the development of what could become the first therapeutic option for this major unmet medical need,” said Abhay Joshi, Ph.D., president and chief executive officer at Alvine. “We are pleased to have an industry leader in gastroenterology as a collaborator, whose considerable global development reach can be focused on getting this novel therapy to more patients.”

This drug was given fast-track status by the Food & Drug Administration in September 2012 and could be on the market in as little as five years.

This brings us back to the important question, would you take a pill which would allow you to eat gluten?

http://www.medicaldaily.com/articles/15521/20130514/future-celiac-disease-treatment-alvine-abbvie-team.htm

 

Post authored by The Gluten-Free Traveller


6 thoughts on “Update on Possible Future Gluten-Killing Drug”

  1. If it was safe? In a heartbeat. It would vastly simplify travel, nights out, and grocery shopping.

    The question becomes, “if such a pill existed and was safe and affordable then why wouldn’t you take it?”

  2. I’ve been taking gluten blockers from the Vitamin World vitamin stores, Sprouts, or CVS has their own brand of digestive enzymes and gluten blockers. I don’t take them and proceed to eat a huge meal of gluten foods but if I’m not sure if there might have been cross at someone’s home or at a restaurant, I always carry them with me. I went to a restaurant recently that said right on the menu, if you have any food allergies, I told the waitress I couldn’t eat any products containing wheat. We’d been going there for 10 years and they always served your choice of a biscuit or cornbread on a bread plate. Well, after telling all that, they changed everything around and the bread now was put on the middle of the plate touching the food!!!!!!!! She didn’t listen to anything I had said or just didn’t care so it was a good thing I had the blockers with me!!!!!! I immediately removed the bread from the plate, handed it to my husband, and went to wash my hands and get the wheat off!!!!! I didn’t eat all the food it had touched but did have some and didn’t feel bad with an immediate stomachache. My last upper endoscopy showed the villi was definitely healing and I don’t overdue gluten-laden food but feel good knowing if there should be an occasion that there is cross contamination or I want to take a small bite of something my husband might be eating, I take the gluten blockers. I noticed a new one on the drug store the other day called “Gluten Cutter” by Healthy Digestives. They say it’s for people who want to still eat gluten and be safe or people who want to stay on the gluten free diet but aren’t sure if there maybe something with gluten in it, like BBQ sauce at a friend’s house.

  3. I’ve been taking gluten blockers from the Vitamin World vitamin stores, Sprouts, or CVS has their own brand of digestive enzymes and gluten blockers. I don’t take them and proceed to eat a huge meal of gluten foods but if I’m not sure if there might have been cross at someone’s home or at a restaurant, I always carry them with me. I went to a restaurant recently that said right on the menu, if you have any food allergies, I told the waitress I couldn’t eat any products containing wheat. We’d been going there for 10 years and they always served your choice of a biscuit or cornbread on a bread plate. Well, after telling all that, they changed everything around and the bread now was put on the middle of the plate touching the food!!!!!!!! She didn’t listen to anything I had said or just didn’t care so it was a good thing I had the blockers with me!!!!!! I immediately removed the bread from the plate, handed it to my husband, and went to wash my hands and get the wheat off!!!!! I didn’t eat all the food it had touched but did have some and didn’t feel bad with an immediate stomachache. My last upper endoscopy showed the villi was definitely healing and I don’t overdue gluten-laden food but feel good knowing if there should be an occasion that there is cross contamination or I want to take a small bite of something my husband might be eating, I take the gluten blockers. I noticed a new one on the drug store the other day called “Gluten Cutter” by Healthy Digestives. They say it’s for people who want to still eat gluten and be safe or people who want to stay on the gluten free diet but aren’t sure if there maybe something with gluten in it, like BBQ sauce at a friend’s house.

  4. I would definitely take the pills when I eat out. Even when restaurants try to be gluten free they often aren’t and I can always tell by the rash I get a few days later. I rarely eat out because of this. It would be great if I didn’t have to be quite as careful. I was under the impression that the “digestive enzymes” mentioned above were kind of a hoax so I have never tried them.

  5. I wouldn’t bother with the pills. I’ve been gluten free since I was 15 (half my life) and I’m so used to it I’d rather stick with it. I’m so sensitive to gluten that I’d be afraid it wouldn’t work entirely. And let’s face it, this medicine will be expensive!! $70 million has already been paid into it and that will get passed down to us.

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